Dashed left edge = started before May 1541 ·
Dashed right edge = ongoing beyond May 1541
Events in May 1541 3
1541Colloquy of RegensburgFailed attempt to reconcile Catholics and ProtestantsCatholic and Protestant theologians, including Philipp Melanchthon and Johannes Eck, met at the Diet of Regensburg under Emperor Charles V to seek doctrinal compromise. Negotiators reached partial agreement on justification but failed to resolve disputes over the Eucharist and church authority. The collapse of the talks hardened the religious division of the Holy Roman Empire.
1541Hernando de Soto Reaches the Mississippi RiverSpanish expedition becomes first Europeans to document the riverHernando de Soto's expedition, marching through the southeastern interior of North America in search of riches, arrived at the banks of the Mississippi River. His party was among the first recorded Europeans to see and cross the river. De Soto died of fever on its banks less than a year later.
1541France Attempts to Colonize CanadaCartier and Roberval launch the Charlesbourg-Royal settlementJacques Cartier sailed to the St. Lawrence valley to found a French colony near present-day Quebec City, in advance of the expedition's commander, Jean-Francois de Roberval. The settlement of Charlesbourg-Royal suffered through a harsh winter, disease, and conflict with the local Iroquoian population. It was abandoned within two years, delaying French colonization of Canada by decades.