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Events on Wednesday 6 May 1536 1
1536Siege of Cusco beginsManco Inca Yupanqui leads a mass uprising against Spanish ruleInca ruler Manco Inca Yupanqui led a massive indigenous army in besieging the Spanish garrison at Cusco, nearly retaking the former Inca capital. The siege lasted roughly ten months before Spanish forces broke it, though Manco Inca continued resistance from a jungle redoubt for decades. It was the most serious indigenous challenge to Spanish rule in Peru.